6-DIAZO-5-OXO-L-NORLEUCINE
L-DON | CAS 157-03-9 | Glutaminase Inhibitor | Beixinke Chem
L-DON (6-Diazo-5-oxo-L-norleucine, CAS No. 157-03-9) is a well-established glutamine antagonist widely used in cancer metabolism research, immunometabolism studies, and glutamine-dependent
pathway investigations. As an irreversible inhibitor of multiple glutamine-utilizing enzymes, L-DON has become an important tool compound for exploring metabolic vulnerabilities in tumor cells and immune regulation mechanisms.
Manufactured under stringent quality control standards, our L-DON is supplied with high purity and comprehensive analytical characterization to ensure reliable performance in research applications.
Technical Specification Sheet：
| Product Name | L-DON (6-Diazo-5-oxo-L-norleucine) |
| CAS NO. | 157-03-9 |
| Molecular Formula(MF) | C₆H₉N₃O₃ |
| Molecular Weight(MW） | 171.15 |
| Purity | ≥99% |
| Analytical Method | HPLC, LC-MS, NMR |
| Appearance | White to off-white powder |
| Storage Conditions | -20°C, protect from light |
| Quality Grade | Research Grade |
| Packaging Specifications | 1g, 5g, 10g |
| Use Statement | For research use only. Not for Human or Veterinary Use |
Application Area :
L-DON is widely used in cancer metabolism research, glutamine metabolism studies, immunometabolism investigations, tumor microenvironment research, metabolic pathway analysis, drug discovery programs, and biochemical research involving glutamine-dependent enzymes and cellular metabolic regulation.
Quality Highlights:
✓ Chemical Purity ≥99.0%
✓ Verified by HPLC, LC-MS and NMR
✓ Excellent Batch-to-Batch Consistency
✓ Stable Packaging and Cold Storage Support
✓ Suitable for Cancer Metabolism and Immunometabolism Research
HPLC Purity Chromatogram — Purity: ≥99% (by HPLC)
A complete analytical data package (including COA, NMR, and MS) is available upon request and will be sent separately via email. Please contact us at: Alice@beixinkechem.com
Why Choose Beixinke Chem?
• Reliable supply of research-grade bioactive compounds
• Comprehensive analytical characterization
• Consistent product quality across batches
• Fast global delivery
• Custom synthesis and process development support
• Expertise in complex pharmaceutical intermediates and small-molecule compounds